with rising incidence globally, especially in Asia. Prognosis depends on multiple clinicopathological factors, buttheir relative impact on survival remains to be fully clarified.Aim: To analyze survival outcomes and identify independent prognostic factors affecting overall survival inpatients with endometrial cancer treated at our institute (Regional Cancer Center).Methodology: This retrospective ‘observational study included 166 patients treated at the Department ofGynecologic Oncology, Kidwai Memorial Institute of oncology and research institute, Bangalore, between 2014and 2019. Clinical, pathological, treatment, and follow-up data were analyzed. Survival was estimated usingKaplan-Meier methods, and prognostic factors were assessed by’ Cox ‘regression analysis.Results: The majority (86.1%) had endometrioid histology with significantly better mean overall survival (83.98months) compared to non-endometrioid tumors (50.21 months, p=0.000). Higher tumor grade and presence oflymphovascular space invasion (LVSI) were associated with poorer survival (p=0.000). LVSI showed a more thanfourfold increased risk of mortality (HR 4.736, p=0.002). Older age (≥70 years) also’ predicted worse out
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