Background: Hepatocellular carcinoma (HCC) ranks additional as the deadliest cancer, and around newly available literature proposes that the existence of chronic kidney illness may worsen the difficulty of important indicators like alpha-fetoprotein (AFP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and even platelet total. Methods: We confirmed a reflective cross-sectional study in three tertiary care centers which consisted of 255 patients with chronic liver bug (CLD) and had different degrees of renal meaning - normal, mild CKD, and simple CKD groups. Creatinine levels, eGFR, AFP, ALT, AST, and palates levels were gained and analyzed using ANOVA, correlation, and multivariate regression models. Results: There was a notable positive relationship between serum creatinine and AFP (r=0.62, p<0.001), whereby the most severely affected CKD patients had serum creatinine levels that were at least four-fold greater than those with normal renal functioning on AFP. With advancing CKD, ALT and AST levels gradually elevated while platelet counts markedly declined. Multivariate regression analysis showed that creatinine level independently predicted elevated AFP with
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