Major advancements in endoscopic techniques have allowed for the minimally invasive endoscopic management of many diseases that previously required surgical intervention. This review briefly describes major advances in endoscopic resection, including endoscopic mucosal resection and endoscopic submucosal dissection; endoscopic ablation, including radiofrequency ablation and cryotherapy; submucosal endoscopy, including peroral endoscopic myotomy and submucosal tunneling endoscopic resection; endoscopic access, including biliary access, pseudocyst drainage and direct endoscopic necrosectomy, and endoscopic gastrojejunostomy; endoscopic management of gastroesophageal reflux disease; and endoscopic management of obesity. Owing to the broad range of topics covered, extensive primary literature is provided for further reference for the interested reader. This review contains 8 figures and 55 references Key words: bariatric endoscopy, direct biliary access, endoscopic mucosal resection, endoscopic submucosal dissection, gastroesophageal reflux disease, gastrojejunostomy, peroral endoscopic myotomy, pseudocyst drainage, radiofrequency ablation, submucosal tumors
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