This review discusses the anatomy and physiology of the stomach. The embryologic origins of the foregut are described, as well as how malformations in development lead to pathology. Color illustrations are included detailing the stomach and its surrounding attachments. The neurohormonal pathways involved in the mechanics of gastric motility and gastric acid secretion are described in detail. The biochemistry involved in the digestion of fats, carbohydrates, and proteins is explained, and a summary table of gut hormones and their source and function has been provided. Additionally, an update on how the knowledge of hormonal pathways governing appetite is being used in pharmaceuticals and bariatric surgery to treat obesity is included. Key words: acid suppression, digestion, foregut, ghrelin, leptin, motility, obesity, stomach, vagus nerve
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