This review focuses on the normal anatomy and physiology of the spleen. The spleen functions as a hematologic organ, filtering blood, metabolizing iron, and acting as a reservoir for blood cells. The spleen, the largest lymphatic organ, also plays a key role in adaptive and innate immunity. This review contains 7 figures of highly rendered artwork and 26 references. Key words: immune system, spleen, spleen anatomy, spleen physiology, splenectomy vaccine guidelines
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