Neurologic complications from cancer and its therapies can significantly impact mortality and morbidity. Early recognition and intervention are key to preventing permanent neurologic injury. This review discusses common and uncommon neurologic complications of cancer, including central nervous system metastases, treatment-related neurotoxicities (including immunotherapies), and paraneoplastic syndromes. Workup and management of these neurologic complications are also addressed. Key words: cancer, chemotherapy, metastases, nervous system complications, paraneoplastic syndromes
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