Adjuvant Radiation for Tissue Extremity and Truncal Sarcomas

In this review, we cover the clinical use of radiation therapy in the treatment of soft tissue extremity and truncal sarcomas. After a brief overview of the seminal trials establishing the efficacy of radiation therapy as a component of limb-preserving therapy, we cover current indications for use and discuss when radiation therapy can be withheld without compromising oncologic outcomes. Controversies in treatment sequencing with surgery are fleshed out with pros and cons for both pre- and postoperative treatment. Finally, different modalities of radiation therapy are discussed and common toxicities are covered. This review contains 3 figures, 1 table and 41 references Key words: brachytherapy, limb preservation, neoadjuvant therapy, radiation therapy, soft tissue sarcoma