Radioiodine in various forms (as sodium iodide and as the iodinated compounds MIBG, LIPIODOL, et al.) has been used as a therapeutic agent in oncology. Differentiated thyroid carcinoma (DTC) has been successfully treated by 131I therapy. Neuroendocrine tumors can be treated by palliative therapy, including Meta 131Iodobenzylguanidine therapy (131I-MIBG). Diagnostic 131I or 123I-MIBG scintigraphy is usually performed to image neuroblastoma and malignant pheochromocytoma. Following the establishment of the diagnosis, 131I-MIBG may be applied as a therapeutic agent but with limited success. Hepatocellular carcinoma (HCC) is treated by surgery only in 10% of patients. In others, palliative therapy should be administered. Radionuclide therapy for this disease is a therapeutic option with a major advantage compared to systemic chemotherapy, estrogen and progesterone therapy, and immunotherapy. 131I-lipiodol can be used to treat HCC without side effects. Compared to untreated patients, those who received 131Ilipiodol, showed significantly better survival and a decreased recurrence rate. The modern aspect of the neoplasm treatment involves radioimmunotherapy with radioiodine and some other
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