Abstract: A vital driving force for chemists to discover novel synthetic protocols is the improvement of more effective synthetic technologies and sustainable methodologies. This is associated with the development of innovative research that stimulates the creative reevaluating of known conceptions. Currently, these robust methodologies, as well as green synthetic procedures, have been designed for the total synthesis of secondary metabolites. Flow chemistry and flow photochemistry have emerged as powerful tools to promote valuable transformations in the total synthesis of natural products as key step(s). Flow chemistry development offers many merits over a traditional batch format, namely a round-bottom flask. The advantages of this green tool comprise waste minimization, simple scale-up, reduction of reaction time, safety betterment as, well as energy and cost efficiency. Flow chemistry comprises a fascinating prospect for the synthesis of promising organic molecules and bioactive complex natural products as it represents a suitable modern synthetic technology for the improvement of sustainable chemistry. Continuous flow chemistry is an assembly of chemical processes carried out
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