Background: Platelet concentrates, including platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and leukocyte- and platelet-rich fibrin (L-PRF),are autologous biomaterials used to enhance tissue regeneration in dentistry. Objective: To review the biological mechanisms, technical protocols, and clinical applications of platelet concentrates, with emphasis on PRF and its advanced formulations. Methods: This narrative review synthesizes current literature on PRP, PRF,A-PRF,i-PRF,and C-PRF, with focus on centrifugation parameters, tube materials, and clinical outcomes in oral surgery, implantology, periodontology, and endodontics. Results: Evidence indicates that PRF accelerates wound healing, promotes angiogenesis, and enhances bone regeneration; innovations such as A-PRF+ and i-PRF suggest improved growth factor release and wider clinical versatility. Conclusions: PRF and its derivatives are cost-effective, autologous biomaterials with broad applications in dentistry; future research should prioritize protocol standardization and integration with regenerative technologies.
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