Objectives: Knee osteoarthritis (KOA) is typically the result of wear and tear andprogressive loss of articular cartilage and may eventually lead to disability. Treatment forKOA begins with conservative methods and progresses to surgical treatmentoptions when conservative treatment fails. This systematic review aims to highlight the latestadvancements in non-surgical interventions to improve the management of this commonmusculoskeletal disorder. Methods: A comprehensive search of sources available in both English and Frenchencompassing various databases such as PubMed, Google Scholar, and relevant medicaljournals in addition to recommendations provided by prominent organizations(EULAR, ACR, SFR, SOFMER, OARSI, ESCEO, NICE, PANLAR, AAOS). Inclusion criteria were good quality systematic reviews, meta-analyses, practice guidelinesexcludingsurgicalKOA treatment. Results:We thoroughly examined a large set of 545 articles and meticulously selected 117 for detailed analysis. This carefully selected set comprised randomized controlled trials, consensus statements, international guidelines, systematic reviews, meta-analyses, cohort studies, and reviews. Qualitative synthesis revealed wide
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