EVALUATION AND CORRELATION OF SERUM ELECTROLYTE PATTERN, MAGNESIUM, LDH AND VITAMIN D LEVELS IN PATIENTS OF HYPO THYROIDISM AT AT ERTIARY CARE CENTRE IN HARYANA

Introduction: Thyroid hormone is a central regulator of body hemodynamics, thermoregulation, and metabolic functions and in the disorders of the thyroid gland, signs and symptoms are often nonspecific. Both subclinical hypothyroidism and hyperthyroidism are associated with an increased risk of disease and alteration in biochemical and physiologic measures. In severe hypothyroidism and myxoedema, hyponatremia was a consequence of enhanced renal water retention mediated by vasopressin. Lactate dehydrogenase (LDH) is an enzyme found in nearly all living cells. It catalyzes the conversion of lactate to pyruvate and back, as it converts NAD+to NADH. However, only a few studies have investigated serum lactate dehydrogenase activity in patients with thyroid dysfunction. Vitamin D acts likea steroid hormone and is presently considered an immunomodulator affecting a wide range of functions. Aim and Objectives: To estimate the levels of serum electrolytes like sodium, potassium magnesium, LDH, and vitamin D in hypothyroid patients and to correlate with TSH. Materials and methods: The study population was serum specimens from 150 patients with hypothyroidism with ages ranging from 25-65 yea