Abstract: Background: Axillary Ultrasound plays an essential role in assessment of axillary lymph nodes metastasis in early breast cancer. It is considered as important prognostic factor in the recurrence of the disease and survival of the patient. Objective: The study was aimed to determine ultrasonography’s diagnostic accuracy taking histopathology as a Gold Standard in finding axillary lymph nodes in early CA breast patients. Materials and Methods: Study was designed as cross-sectional, conducted at Department of radiology, Liaquat National Postgraduate Medical Center, Karachi. The sample size calculated for the study was 271. Patients of age between 18-65 years were included in the study. Sensitivity, specificity, PPV, NPV and diagnostic accuracy were calculated. Result: The mean age of the participants was 46.28 ± 9.76 years. The age range from 25 years to 78 years. The study has yield a sensitivity of 76.9% whereas specificity was reported 68.2%. The overall diagnostic accuracy of AUS was observed as 74%. A positive predictive value and negative predictive value was 88.8% and 52.7% respectively. Conclusion: The findings of this study provides information related to the diagn
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