LASER SURGERY OF NEVUS OF OTA AND NEVUS OF ITO

Introduction. Clinical variants of congenital melanocytosis in the dermis- nevus of Ota and nevus of Ito (NOI) - may cause marked cosmetic effects; they fail to regress and are reported to be associated with the risk of malignancy. Purpose. To develop criteria and the algorithm for selecting the optimal laser system and radiation specifications to remove NOI considering specific properties of the optical pattern of skin lesions having different locations and melanin concentration. Methods. A scientific and analytical review of publications indexed in PubMed, ScienceDirect, Embase, Web of Science, Russian Medicine, RSCI. Calculation of laser radiation absorption coefficients for various pathomorphological variants of dermal melanocyte locations, given the peculiarities of laser light interaction with targeted photothermophores in NOI focus. Results. The authors present data on epidemiology, history and clinical features of congenital derma melanocytosis of nevus of Ota and nevus of Ito (NOI) - localized, predominantly in periocular and periclavicular regions. Molecular mechanisms of NOI progression in children and adolescents are discussed. There are also data [WU1] on the efficacy