Background: There is growing momentum toward performing laparoscopic cholecystectomy as a day-case procedure for suitable patients. Nonetheless, surgeons still report barriers to same-day discharge. The purpose of this study was to compare day-case laparoscopic cholecystectomy with conventional overnight-stay laparoscopic cholecystectomy in selected patients with gallbladder stones. Methods: A prospective comparative observational study was conducted in the Department of Surgery, DHQ Abbottabad, from June 2024 to July 2025. Seventy ASA I patients aged 20–50 years with uncomplicated gallstone disease were allocated to day-case discharge within 12 hours (Group 1, n=35) or discharge after 24 hours (Group 2, n=35). Outcomes included operating time, VAS pain at 6 hours, postoperative nausea and vomiting, complications, readmission, time to return to normal home activities and satisfaction. Results: Baseline age and BMI were comparable between groups. Mean operating time was 40.43±4.42 minutes in Group 1 versus 40.57±4.05 minutes in Group 2 (p=0.888). VAS pain at 6 hours was 3.23±0.84 versus 3.14±0.91 (p=0.684). Return to normal activities was 4.94±1.76 days versus 4.49±1.80 days (p=0.28
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