The clinicoimmunologic observation of 85 patients with generalized forms of epilepsy, different in the course of the disease, as well as with medicamental resistance is performed. It is found that there is no an autorecognition defect in the reaction of lymphocytes of the mixed culture in the second time generalized form of epilepsy with favoriable course. In progradient course and medicamental forms the decreased proliferative reaction of lymfocytes showing the same nature of immunopathologic changes takes place. The results obtained suggest the possible importance of autoimmune disorders in pathogenesis of progradient course of epilepsy.
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