BACKGROUND: Experimental animal models of peri-implantitis are needed to predict complications after dental implant placement and the use of various suprastructure materials, as well as to improve treatment for this complication. In this context, the development of an alternative, technically simple, and well-controlled method suitable for preclinical studies — aimed at investigating the pathogenesis of inflammatory complications in dental implantation and improving prevention and treatment strategies — is a promising direction. AIM: To develop and test an experimental model of peri-implantitis (inflammation of the soft tissues around an integrated implant) in vivo in the canine mandible for subsequent evaluation of the restoration of the "implant–gingiva" and "implant–bone" interfaces, as well as methods for prevention and treatment of this complication of dental implantation. METHODS: A method for inducing peri-implantitis by placing a non-sterile rubber ring between the gingival former and the soft tissues in a dog is proposed and tested for the first time. The model is based on mechanical gingival irritation without microbial contamination, and avoids bone trauma and addition
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