Background: Various innovative solutions are being adopted in dentistry to reduce the risk of treatment-related complications. Latest-generation adhesive systems are important for preventing microleakages and improving the adhesion of filling materials to tooth structures, resulting in effective use of esthetic restoration materials and long-lasting restorations. Aim: To assess the current use of universal adhesive systems. Materials and methods: The literature search was performed using PubMed, eLIBRARY.RU, and Google Scholar. The following search terms were used: “universal adhesive systems”, “universal adhesives”, “dentin bonding agents”, “dental debonding” and “dental etching”. The search covered studies published during the last 10 years. Results: The initial search yielded 1.284 publications. After screening for compliance with search terms, 106 studies were selected. Following a full-text analysis, 31 (100%) publications were included in the review. Of these, 14 (45%) studies addressed adhesive composition (examined component: hydrophilic monomers, nanofillers, hydrophobic monomers, solvents, etchants); 8 (26%) studies addressed adhesive strength of adhesives (air-powder
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