Introduction. Colorectal cancer, including cancer of the transverse colon, is known for its potential to metastasize to distant organs. Although the liver and lungs are common metastatic sites, metastasis to the vagina is rare and poses unique challenges for treatment. Methods. This case report details a rare instance of vaginal metastasis in a 58-year-old patient with advanced transverse colon adenocarcinoma. According to our experience, intracavitary brachytherapy of metastasis into the vagina is not effective, especially in cases of volumetric tumors. Results. As a rule, we use interstitial brachytherapy with an intracavitary applicator of maximal diameter. Over a 24-month follow-up period, there was no local recurrence or progression of the disease, along with improved quality of life for the patient. Conclusions. This case highlights the importance of personalized treatment approaches and underscores the need for further research to optimize brachytherapy protocols for the effective treatment of rare metastatic sites in colorectal cancer.
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