Efficacy and tolerability of Seizar (lamotrigine) in the treatment of epilepsy (experience of Svt. Luka’s Institute of Child Neurology and Epilepsy)

Background. We have accumulated extensive experience in the use of lamotrigine in patients with epilepsy; its mechanism of action, effectiveness, safety, and tolerability are well known. The results of numerous studies indicate its high efficacy and potentially better tolerability compared to other drugs in the treatment of a wide range of epilepsy forms and epileptic syndromes (focal and generalized seizures). These characteristics of lamotrigine determined its priority administration as initial or alternative monotherapy in women with epilepsy. Objective: to review efficacy and tolerability of Seizar in patients with various forms of epilepsy based on long-term experience of using this drug in our center. Materials and methods. We analyzed therapeutic effects of Seizar in 22 patients aged between 3 and 34 years (mean age 15.3 years) treated in Svt. Luka’s Institute of Child Neurology and Epilepsy. The sample included 8 adults and 14 children (under 18 years of age), including 6 children aged from 3 to 12 years. Ten patients were male and twelve patients were female. Study participants were diagnosed with the following forms of epilepsy: idiopathic (genetic) generalized epilepsy (