The utilization of composite materials as alternatives to Ordinary Portland Cement (OPC) is essential in mitigating the environmental impact of cement production. This study investigates the potential of industrial by-products rich in silica and alumina, such as fly ash (FA), alccofine (ALC), and nano silica (CNS), to partially replace OPC in concrete. Tetranary blended nano concrete (TBNC) compositions, incorporating 25% FA, 10% ALC, and varying proportions of CNS (0%, 0.5%, 1%, 2%, and 3%), were examined for their compressive strength in M30 and M60 grade concrete following a 90-day curing period. Results demonstrate the significant influence of CNS on compressive strength of TBNC. To validate these findings, Response Surface Methodology (RSM) was employed for mathematical modeling and statistical analysis, predicting compressive strength values and comparing them with experimental data. This research underscores the viability of utilizing industrial by-products in concrete production, thereby promoting sustainable construction practices
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