Introduction: Wilms’ Tumor is a malignant renal neoplasm that frequently occurs in children during the first decade of life. Clinically, it is a rapidly growing abdominal mass that causes low back pain and hematuria. Computerized axial tomography or nuclear magnetic resonance are fundamental for its diagnosis, and chemotherapy and surgery have become first-choice treatments. After diagnosis, the majority of treatment plans involve the administration of antineoplastic drugs, whose side effects may include mucositis, candidiasis, xerostomia, caries, and worsen other previously diagnosed lesions, regardless of the organ affected by the tumor. Treatment is more effective if provided by a multidisciplinary team in which the dentist plays a significant role in the implementation of an integral oral care protocol. In the present study, the management of a pediatric patient under antineoplastic treatment for Wilms’ tumor is reported. Case report: A four-year-old female patient diagnosed with Wilms' tumor, who required antineoplastic treatment. She had temporary dentition with early childhood caries, irreversible pulpal lesions and agenesis of teeth 72, 82, and the germ of tooth 42. The pat
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