ANTITUMOR EFFECTIVENESS OF THE COMBINED APPLICATION OF BACTERIA OF THE GENUS BIFIDOBACTERIUM AND B. SUBTILIS IMV B-7724 LECTIN

Summary. Aim: to investigate of the antitumor effectiveness of the combined use of bacteria of the genus Bifidobacterium and the extracellular metabolite (lectin) of B. subtilis IMV B-7724. Object and methods: studies were performed on Balb/c mice (n = 52). Ehrlich adenocarcinoma was used as an experimental model. Starting from the 2nd day after the transplantation of tumor cells, the animals of the experimental groups were injected with lectin B. subtilis IMV B-7724 (s/c, 1 mg/kg of body weight, No. 10), B. animalis (per os, 7×105 CFU/ mouse, No. 10) or used their combination. The frequency of transplantation (%), the latent period of tumor emergence, the volume of tumors (mm3), and the life expectancy of animals were evaluated. Statistical processing of the results was carried out according to generally accepted methods of variational statistics. Results: administration of B. subtilis IMB B-7724 lectin (both alone and in combination with B. animalis) to mice with Ehrlich adenocarcinoma resulted in a significant inhibition of tumor growth. The tumor growth inhibition index was 55.0 and 50.5%, respectively. the animals of these groups were also characterized by a statistically sign