Summary. Aim: to evaluate lymphocytic infiltration and lymphovascular invasion in endometrioid carcinoma of the endometrium depending on the clinical and morphological features of the patients. Object and methods: pathohistological findings of samples of surgical material of 247 patients with endometrioid carcinoma of the endometrium (ECE). Methods: immunohistochemical, cytofluorometric, statistical, bioinformatics, ROC analysis. Results: in the analysis of pathohistological findings, it was established that 44.1% of ECE have slight lymphocytic infiltration (LI), 55.9% have significant LI. In the group of endometrial carcinoma with a insignificant LI it is established a larger amount of G3 tumors with deep invasion in the myometrium (26.0%) compared to the group of tumors with significant LI (17.0%, p < 0.05). A low content of CD8+-lymphocytes, a large number of FOXP3+-lymphocytes and a density of microvessels are found in G3- and deeply invasive tumors. Lymphovascular invasion (LVSI) was observed in 63.3% of such tumors, which was associated with high Snail1 expression, low E-cadherin, a decrease overall and recurrence-free survival of patients with this oncopathlogy. Conclusio
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