Summary. Aim: to assess the effectiveness of the combined use of immune and chemotherapy with different metastatic tumors. Object and methods: two experimental models were used: Ehrlich adenocarcinoma (ACE) and Lewis lung carcinoma (CLL). As a means of chemotherapy used cisplatin, biotherapy – B. subtilis IMB B-7724 lectin, which in low concentrations has immunostimulating activity. Animals of different groups were introduced in mono-mode or theіr combination. The standard tumor growth and metastasis rates were evaluated. Upon completion of treatment, the activity of nonspecific immunity effectors was evaluated. The statistical analysis of the results was performed according to the generally accepted methods of variation statistics. Results: on both models of tumor growth, antitumor and antimetastatic efficacy is demonstrated as a means of immunotherapy of B. subtilis IMB B-7724 lectin. The severity of the effect depended on the mode of its introduction (mono-mode, combination with chemotherapy) and model tumors: for mice with ACE more effective was the introduction of lectin in mono-mode (the tumor growth index, TGI=53,2%); with LLC – combined injection of lectin and cisplatin (T
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