Summary. The present paper is a review on the literature data and our research, concerning a role of the retinoblastoma (RB) protein in pluripotent stem cells (SCs) proliferation and differentiation. The role of RB in the cell cycle, in development of pathological conditions, in the control on cell differentiation, and in epigenetic regulation of expression of the SC-specific genes is discussed, in the light of protein-protein interactions. The present review might be useful for the further studies and understanding of SC properties, as well as the effectiveness of use of SCs in medical practice.
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