Summary. Altered metabolism is one of the key molecular characteristics of prostate cancer (PCa). The search for new tissue biomarkers that could be used for diagnosis, assessment of aggressiveness and risk of progression of PCa is an urgent problem. In this regard, polyamines (PA) — spermine (Spn), spermidine, putrescine — substances necessary for cell proliferation and growth deserve special attention. Aim: to investigate PA levels in postoperative and biopsy specimens of benign and malignant human prostate tumors to determine the potential for their use for more accurate differential diagnosis, assessment of the aggressiveness of PCa and the risk of disease progression. Object and methods: the study was conducted on 120 postoperative samples from patients with PCa (n = 100) and with benign prostatic hyperplasia (BHP, n = 20), as well as on 40 samples obtained in multifocal trepanbiopsy of prostate (20 samples of malignant tissue and 20 samples of benign tumor tissue). The method of highperformance liquid chromatography (HPLC) was used to determine PA. Statistical processing of the results was carried out by the methods of variational statistics using standard licensed computer p
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