Feline panleukopenia (FPL) is a fatal, transmissible disease in cats and other members of the Felidae family. A meta-analysis was performed to determine the worldwide prevalence of FPL infections in domesticated cats. This meta-analysis was finalized according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After a competent search, data extraction and identification of qualified articles were performed. Data were analyzed using a specific software program for meta-analysis, and the results included weight, effect size, publication bias, and heterogeneity. A total of 5820 domesticated cats from 36 accepted studies were investigated for FPLV infections. Of all, 2928 cats were found positive for FPLV infection, with a prevalence of 50.30%. The prevalence of FPL in cats varied significantly between countries (p < 0.001). The highest prevalence was recorded in Germany (15.81%), whereas the lowest prevalence was recorded in Korea (2 %). The Z-values were -10.935 (P = 0.000) and -2.903 (P = 0.004) for fixed and random effects, respectively. The Q-value (948.37), I-squared (96.309), and P (0.000) were the final heterogeneity variables. Mor
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