Objectives: To evaluate mineral loss and lesion depth of enamel adjacent to different ion-releasing resin composites in conjunction with artificial caries induction, and to evaluate shear bond strength to enamel. Methods: Three ion-releasing resin composites (ACTIVA™ BioACTIVE-RESTORATIVE™, BEAUTIFIL Injectable XSL and Cention® N) with or without adhesive system were investigated in comparison with a conventional resin composite (Filtek™ Z350 XT). Effect of Caries Inhibition in Adjacent Enamel – 36 human premolars with cylindrical cavities and filled with restorative materials underwent 14 days of artificial caries induction and were sectioned into two cross-sectional specimens (n=12). Mineral loss and lesion depth were measured at 10, 260, 510, and 760 μm from the tooth-restoration interface and analyzed using repeated measures ANOVA and pairwise comparison for within group comparisons (p<0.05) and One-way ANOVA with Tukey’s post hoc test for comparisons among groups (p<0.05). Shear bond strength test – 108 human premolars were embedded in self-curing acrylic resin. A polyethylene tube was placed on each surface and filled with restorative materials. Each group was divided
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