Objectives: This study aimed to evaluate the remineralization efficacy of nano-strontium/ fluoride hydroxyapatite paste on initial enamel caries in comparison with other remineralization products under a simulated pH-cycling model. Methods: Following the artificial caries induction, forty enamel specimens with noncavitated lesion in the same range of lesion depth were selected by mean of micro-CT evaluation. The specimens were block-randomized into four experimental groups regarding remineralizing pastes: 1500 ppm sodium fluoride paste, 10%wt nano-hydroxyapatite paste, 10%wt nano-strontium/fluoride hydroxyapatite paste and 5%wt nano-strontium/ fluoride hydroxyapatite paste. Remineralizing effect was evaluated using micro-CT, while SEM/EDS line scan mode facilitated the investigation of remineralization patterns. Changes in lesion depth (ΔLD) and changes in mineral loss (ΔΔZ) were evaluated at 7 and 14 days of treatment under the pH-cycling model. Statistical analyses were performed using 2-way ANOVA and post hoc Tukey’s test (p<0.05). Results: The use of 5%wt nano-strontium/fluoride hydroxyapatite paste significantly reduced lesion depth in initial caries under experimental co
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