Objectives: This study aimed to investigate the effect of self-etch silane contamination on dentin bond strength to resin composite when using different adhesive systems. Methods: 40 flat occlusal dentin surfaces were prepared and randomly divided into 4 groups (n=10): group ER (Optibond FL); group SE (Clearfil SE bond); group SiER and group SiSE (Monobond Etch and Prime (MEP) followed by Optibond FL and Clearfil SE bond, respectively). Microtensile bond strength (µTBS) data was analyzed by two-way and one-way ANOVA followed by the post hoc Tukey honest test. The failure mode data was analyzed using Pearson Chi-square test. After undergoing different contamination procedures (distill water, phosphoric acid, and acidic primer with and without MEP contamination), 6 additional specimens were analyzed by scanning electron microscopy (SEM). Results: The two-way ANOVA indicated that the adhesive system and silane contamination significantly influenced the µTBS. µTBS (MPa) of all (ER 47.79±3.48; SiER 41.16±11; SE 39.77±3.16; SiSE 35.10±4.12) groups were significantly different from each other, except for the SE versus SiER group. The silane contamination significantly decreased the µTBS
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