Background: Gamma-hydroxybutyric acid (GHB) is classified as a category I psychotropic substance in Thai legislation. It can be exogenously consumed or endogenously produced and cut-off concentrations are required. Baseline GHB concentration ranges in Thai postmortem cases are still not available. Objectives: To determine baseline GHB concentrations and factors influencing GHB concentrations in Thai postmortem cases. Materials and methods: Postmortem femoral and cardiac blood samples were collected from Thai cadavers aged 18 years old or older sent for medico-legal autopsies at the Department of Forensic Medicine, Siriraj Hospital, Mahidol University between 18th August 2021 and 25th January 2022 with postmortem interval (PMI) not greater than 24 hours. Case data including sex, age, PMI, sites of collection and causes of death were recorded. Blood GHB concentrations were extracted using protein precipitation and analyzed by gas chromatography-mass spectrometry (GC-MS). Descriptive statistics, paired samples Wilcoxon signed-rank test, Spearman's correlation, Mann-Whitney U test and Kruskal-Wallis H test were analyzed where appropriate. Results: A total of 150 subjects were rec
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