After I had agreed to give this talk about Lionel Penrose's contributions to genetics and mental deficiency I realized what an impossible task I had undertaken. His research career in these areas spanned a period of more than forty years, during the whole of which he was making important and significant contributions on an extraordinarily diverse range of topics. Furthermore, during this period both of these subjects advanced from an almost pre-scientific infantile state to rigorous and critical disciplines, and Penrose's work played no small part in this development.
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