Abstract Background Multisite pain is common during adolescence and is influenced by sex-related neurobiological and developmental factors, but its developmental neural mechanisms are unclear. Methods Utilizing data from the Adolescent Brain and Cognitive Development Study, we investigated the relation between cortical brain structure and multisite pain (assessed by youth self-reports of painful regions on a body map) in male ( N = 3,299) and female ( N = 2,844) adolescents aged 11–12 years. We focused on brain regions functionally linked to multisite pain (i.e., bilateral sensorimotor, cingulate, fronto-insular and inferior parietal cortex). We also explored the moderating role of pubertal status (assessed by the Pubertal Development Scale). Results Findings revealed distinct brain structure-pain associations in male and female youth. Mal
📖 افتح في inklap 🔗 DOI 📮 اطلب بحثاً