Abstract Background The COVID-19 pandemic presented an unprecedented challenge to global health systems worldwide, exposing structural strengths and vulnerabilities. Morocco, following WHO guidance, implemented a national strategy based on health, economic, and social pillars. This study presents a regional descriptive analysis of the implementation of Morocco’s National COVID-19 Response Plan in the Fez-Meknes region, based on aggregated and administrative data collected from official epidemiological and vaccination information systems. Objective This study analyzes the strategy’s implementation in the Fez-Meknes region (March 2020–December 2021), detailing activities, outcomes, strengths, weaknesses, and lessons for future resilience. Methodology Despite limited resources and regional disparities, the Fez-Meknes health system mobilized quickly to launch key interventions: early surveillance, expanded testing, care reorganization, home isolation, and mass vaccination. T
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