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Secular trends in age at menarche among Han Chinese females in Shanghai: a large-scale community-based study

Xiaoli Xu, Genming Zhao, Xing Liu, Na Wang, Xiaohua Liu, Yonggen Jiang · BMC Women's Health · 2025

Abstract Background Menarche, marking the onset of female reproductive potential. Understanding the secular trends in age at menarche (AAM) is crucial for public health, as earlier menarche is associated with adverse health outcomes in adulthood. This study sought to explore the long-term trends of AAM among Han Chinese females in Shanghai, China, and to explore its correlation with overweight/obesity in adulthood. Methods We utilized baseline data from the Shanghai Suburban Adult Cohort and Biobank (SSACB), a large-scale community-based study. A total of 38,396 Han females born between 1942 and 1995 were included. Participants were divided into 11 birth-year cohorts and five percentile groups (10th, 25th, 50th, 75th, and 90th) based on AAM. The overweight/obesity status was defined using BMI criteria. Quadratic and quantile regression analyses were conducted to evaluate the time trends of AAM. Results The mean AAM decreased from 17.45 ± 2.50 years

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