Objective: To review the past half century of North American psychiatry from personal experience and to gauge its future prospects. Method: An examination of the relevant literature, recollections from a long academic career, and analysis of trends. Results: The pendulum of psychiatric theory continues its swing from its psychological to its biological pole; current economic forces are driving it toward reductionistic biology. The very considerable gains in the npsychosocial and neurobiogical knowledge base of our field will ultimately have a potent yield in patient care once the restrictive controls on its application to service provision are lifted. Conclusion: The future of research in the sciences basic to psychiatry has never been more promising. How rapidly rogress will occur will be a function of the resources society is willing to commit to mental health research. The prognosis for the translation of the
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