The rate of cell division during a 6-hour period of time was determined in cervices from 31 mice, 16 having normal epithelium, 8 with atypical epithelium and 7 with invasive carcinoma. Cervical atypias and carcinoma were induced by local application of benzo(a)pyrene (BP) and mitosis was arrested with vincristine. Values for the ratio of dividing cells in the parabasal layer to the total number of cells in all layers as well as the proportion of dividing cells in the parabasal layer were significantly greater in atypias and invasive carcinoma than the values found in normal epithelium. Atypical and malignant parabasal cells may contribute to tumor growth through a proportional increase in cell production in that layer.
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