In vivo and in vitro investigations of a Syrian hamster tumor metastasis in the lymph node (H<sub>10</sub>Z<sub>m</sub>) in comparison with the primary tumor (H<sub>10</sub>Z) are performed. It is shown that the metastasis differs from the primary tumor by the prevalence of M secondary cell type characterized by globulous appearance, decreased adhesion and the presence of two long submetacentric marker chromosomes. Since a cell type with such cytogenetical characters was also found in the primary tumor as well as in a non-metastasizing tumor variant, it is suggested that the role of the induction-selection phenomenon in the occurrence of H<sub>10</sub>Z tumor metastases, i.e., new inductor agents occurred in the tumor’s environment, might produce the induction of certain repressed mutant genes in M secondary cell type, bringing about certain phenotypical alterations (e.g., the decrease of the mutual cell adhesion) which could favorize the migration and selection of this cell type.
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