The treatment of advanced breast cancer patients has been clarified through the efforts of prospective, randomized studies on large populations. Treatment is palliative, using single agents in a sequential manner, with close follow-up of results. Premenopausal patients undergo castration with subsequent treatment consisting of hormones or chemotherapy in castration failures or further endocrine ablation in castration responders. Postmenopausal females undergo treatment with androgens, estrogens or a combination of corticosteroids and triiodothyronine with endocrine ablation reserved for hormonal failures. Radiotherapy is used for treatment of localized disease, bone pain or impending fracture.
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