In the present study a new method for evaluating left ventricular chamber compliance is reported. We induced a programmed postextrasystolic beat during routine left ventricular angiography through a temporary pacing catheter, placed at the sinuatrial junction (S1-S1 = 600 ms; S1-S2 = 400 ms; S2-S3 = 800 ms). Thirty-two patients with documented critical coronary artery disease and 5 normal subjects represent the study group. The method allows to have two couples of end-diastolic pressure and end-diastolic volume and we calculated the modulus of chamber stiffness with the formula: K = (In EDP 3 – In EDP 1)/ (EDVI 3 - EDVI 1), where EDP 1–3 and EDVI 1–3 are end-diastolic pressure and end-diastolic volume index in basal beat and in the postextrasystolic pause, respectively. Left ventricular chamber compliance (dV/dP) and specific compliance (dV/VdP) were also calculated. In order to assess the clinical value of the method, we divided the patients with coronary artery disease into three groups: 12 patients had angina and no previous myocardial infarction; 15 had a previous myocardial infarction and responded to postextrasystolic potentiation with an increase in left ventricular ejection
📖 افتح في inklap 🔗 DOI 📮 اطلب بحثاً