A variety of factors may change the normal distribution of bone‐seeking radiopharmaceuticals. This paper presents a classification of non‐skeletal bone tracer distribution according to physiologic, pathologic, and artifactual causes. The mechanisms thought to account for non‐skeletal distribution are reviewed. Examples of non‐skeletal bone tracer distribution include calcinosis cutis and pulmonary mineralization in hyperadrenocorticism, renal infarct, acute rhabdomyolysis, urine contamination, lymph node uptake following extravasation of the radiopharmaceutical, thyroid uptake due to free pertechnetate in the injectate, and intramuscular uptake following injection of butorphanol.
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