Hyperthermia is a field of cancer research of increasing importance to veterinarians and physicians. The thermobiologic studies that are guiding the development of clinical research are reviewed. The interaction of heat, radiation, and drugs on tumors and normal tissues is presented, and the basis for producing a therapeutic gain is discussed. Current methods of inducing local, regional, and systemic hyperthermia in animals and humans are summarized. The areas of clinical research in which veterinary radiologists and oncologists could contribute by studying the effects of heat and radiotherapy on domestic animals with spontaneous tumors are emphasized.
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