ABSTRACT Objective:The existence of positive‐outcome bias in the medical literature is well established. Positive‐outcome bias in two emergency medicine journals was compared with that found in two general medicine journals. Methods:Published original contributions from Annals of Emergency Medicine, American Journal of Emergency Medicine, JAMA, and New England Journal of Medicinewere reviewed. Articles were categorized as demonstrating a positive or negative outcome or showing no difference using new criteria. Descriptive articles were excluded. Results:Of 700 articles reviewed, 177 emergency medicine and 211 general medicine articles met the study criteria. The emergency medicine journals had 142 articles (80%) with positive outcomes, 27 (15%) with negative outcomes, and 8 (5%) with no difference. The general medicine journals had 169 articles (80%) with positive outcomes, 33 (16%) with negative outcomes, and 9 (4%) with no difference. There was no significant difference between journal groups (chi‐square; p = 0.99). The power of the study was 0.80 to detect a difference of 15% between groups with alpha set at 0.05. Conclusions:There was no significant difference in the proportion
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