Summary1. The present paper consists of observations made from the anæsthetist's angle in seventy‐seven operations upon the brain or spinal cord.2. These operations have been classified in terms of the site of the lesion, the anæsthetic technique employed and the operative mortality.3. Of the sixty‐three patients concerned in the present report, four (6.4%) succumbed during operation and fourteen (22.2%) during the postoperative period. The remaining forty‐five were well when they left hospital, although not necessarily benefited by operation.4. Details are given of four fatalities on the operating table.5. The duties of the anæsthetist are discussed in terms of preoperative examination of the patient, administration of the anæsthetic, keeping of the operation record and combating of shock.6. The anæsthetist's equipment is detailed.7. The scope of certain anæsthetic methods (local, local with inhalational supplement, endotracheal use of ether, and endotracheal use of nitrous oxide) is discussed, together with notes on pre‐operative sedation in each group.8. Detailed consideration is given to the apparent causes and to the treatment of shock and respiratory embarrassment during cere
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