AbstractThis paper describes a method which may be used to determine conjugation of iodipamide and ipodate in plasma, bile and urine. Using ‘“I‐labelled contrast agents, conjugation was determined by thin‐layer chromatography, before and after beta‐glucuronidase incubation of samples. This method achieves a high degree of sensitivity. It was found that ipodate is excreted in dog bile principally as the glucuronide conjugate. Excretion of a small amount of iodipamide as a glucuronide conjugate was also detected.
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