SummaryThe length of the infection cycle of double‐stranded DNA bacteriophages is controlled by phage‐encoded small integral membrane proteins, holins. Holins are the gatekeepers of the lysis process, possessing an intriguing ability to be triggered, at a precise time point, to form large holes in the cytoplasmic membrane of phage‐infected bacteria. The paper by Savva et al. in this issue of Molecular Microbiology invites us to take a closer look at this membrane lesion. For the first time, a structural characterization of large‐diameter rings formed by these peculiar membrane proteins is presented.
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