SummaryMany differentiation processes in both prokaryotes and eukaryotes begin with an asymmetric division, producing ‘daughter’ cells that differ in size and developmental fate. This is particularly obvious in the well‐studied prokaryotic lif cycles of Caulobacter and Bacillus. In no system, however, is the mechanism of asymmentric division understood. Here I propose a model for the mechanism o asymmetric division during sporulation in Bacillus subtilis. The model explains bth the timing and asymmetric localization of spore‐septum formation. It also explains the morphological phenotypes of various asporogenous (spo) mutants.
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