SummaryElectrophoretic variants of mitochondrial aldehyde dehydrogenase (AHD‐A2) are widely distributed among inbred strains of Mus musculus and have been used to localize the gene encoding AHD‐A2(Ahd‐1) at the non‐centromeric end of chromosome 4.In the mouse (Mus musculus), aldehyde dehydrogenase (AHD; E.C.1.2.1.3) exists as at least three isozymes which are differentially distributed in liver subcellular fractions (designated A2, B4 and Cy* for the mitochondrial, soluble and microsomal isozymes respectively) and in various tissues of this animal (Holmes, 1978a; 1978b; Timms & Holmes, 1981). Electrophoretic variants have been previously reported for the A2 and B4 isozymes among inbred strains of mice, and the genetic loci (designated Ahd‐1 and Ahd‐2) have been localized on chromosomes 4 and 19 respectively (Holmes, 1978b; Timms & Holmes, 1980). This paper describes further genetic analyses of AHD‐A2 enabling Ahd‐1 to be positioned at the non‐centromeric end of chromosome 4.Forty‐three inbred strains of Mus musculus were used in these studies (Table 1). Two series of matings were carried out.1) Female SM/J mice and male NZC/B1 mice were mated to obtain F, female offspring w
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