BackgroundIntravenous (IV) midazolam may be of value as an alternative paediatric dental sedation technique, but there is some apprehension concerning its routine use due to a lack of evidence regarding its safety and side effects.AimTo review all available literature reporting the side effects of IV midazolam in children undergoing dental procedures.DesignBoth randomised controlled trials (RCT) and non‐randomised studies were reviewed. Reported side effects were categorised as either significant or minor, and the percentage prevalence of significant or minor side effects per episode of treatment was calculated.ResultsFive RCTs were included, in which no significant side events were reported; however, minor side effects were recorded (n = 33, 19.5%), with paradoxical reaction being the most common (n = 11, 6.5%). Six non‐randomised studies were included, in which no significant side effects were reported; however, minor side effects were reported (n = 118, 16.8%) with paradoxical reaction being the most common (n = 89, 12.7%).ConclusionsAlthough no significant side effects were recorded, of the minor side effects reported paradoxical reaction was the most common. Due to inconsisten
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